Inbreeding depression for litter size in two mice lines under divergent selection for environmental birth weight variability using genomic data.

ABSTRACT: Inbreeding depression (ID) is usually observed as reduced survival and fertility and may have a variable impact in different populations. The aim of this study was to estimate ID from genomic and pedigree data in the litter size (LS) of the high variability (H-Line) and the low variability (L-Line) mice lines divergently selected for environmental birth weight variability. Of these, the L-Line performed better on traits related to robustness. A total of 1587 females from 26 selection generations were genotyped with a high-density SNP array. LS data of 732 L-Line and 648 of H-Line animals were used. The following were calculated: pedigree inbreeding coefficient (FPED), genomic inbreeding derived from different genomic matrices (FNEJ, FL&H,FVR1, FVR2, and FYAN), from runs of homozygosity (FR

SUBMITTER: Ojeda-Marin C 

PROVIDER: S-EPMC11914883 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature