Molecular screening to track ceftriaxone-resistant FC428-like <i>Neisseria gonorrhoeae</i> strains' dissemination in four provinces of China, 2019 to 2021.

ABSTRACT: BackgroundThe global dissemination of ceftriaxone-resistant Neisseria gonorrhoeae FC428-like strains poses a public health concern. To assess and follow their spread, establishing effective antimicrobial resistance (AMR) surveillance systems is essential.AimThis study aimed to track ceftriaxone-resistant FC428-like strains in parts of China, using a molecular screening tool.MethodsSamples were collected from Sichuan, Zhejiang, Shanghai, and Guangdong provinces between 2019 and 2021. We employed a rapid molecular tool - the high-resolution melting analysis-based FC428 (HRM-FC428) assay, to screen for FC428-like strains. All FC428-like strains detected were further characterised by genotyping and PCR-sequencing.ResultsOf 1,042 tested samples, 44 harboured the penA-60.001 allele

SUBMITTER: Xiu L 

PROVIDER: S-EPMC11914965 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature