Unveiling racial disparities in prostate cancer using an integrative genomic and transcriptomic analysis.

ABSTRACT: Prostate cancer exhibits significant racial disparities, with African American (AA) individuals showing ∼64% higher incidence and 2.3 times greater mortality rates compared to their Caucasian (CA) counterparts. Understanding the complex interplay of genetic, environmental, lifestyle, socioeconomic, and healthcare access factors is crucial for developing effective interventions to reduce this disproportionate burden. This study aims to uncover the genetic and transcriptomic differences driving these disparities through a comprehensive analysis using RNA sequencing (RNA-seq) and exome sequencing of prostate cancer tissues from both Black and White patients. Our transcriptomics analysis revealed enhanced activity in pathways linked to immune response and cellular interactions in AA prostate c

SUBMITTER: Elbialy A 

PROVIDER: S-EPMC11914995 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature