SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis.

ABSTRACT:

Introduction

Skin aging is a complex, multifactorial process involving cellular damage, inflammation, and increased susceptibility to diseases. Despite its importance, the role of SPRY1 in skin aging remains poorly understood. This study aims to investigate the function of SPRY1 in skin aging, particularly its impact on macrophage M1 polarization, and explore its potential as a therapeutic target for mitigating skin aging and melanoma.

Methods

Bioinformatics analyses were performed using datasets from the GTEx and GEO databases, alongside in vitro cellular experiments. These included Weighted Gene Co-expression Network Analysis (WGCNA), single-cell sequencing, and various cellular assays in RAW264.7 murine monocyte/macrophage leukemia cells and NIH/3T3 mouse skin fibroblasts

SUBMITTER: Zhao R 

PROVIDER: S-EPMC11915026 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature