Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [^99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study.

ABSTRACT: Radionuclide imaging of prostate-specific membrane antigen (PSMA) expression can be used for staging prostate cancer. The pseudo-peptide [^99mTc]Tc-BQ0413 demonstrated high affinity and specificity to PSMA in preclinical evaluation. The purpose of this study was to clinically evaluate the safety and tolerability of a single administration of [^99mTc]Tc-BQ0413 as well as study its biodistribution using SPECT to estimate dosimetry. [^99mTc]Tc-BQ0413 was studied in a single-center diagnostic Phase I open-label exploratory study. Whole-body planar scintigraphy and SPECT/CT imaging were performed 2, 4, and 6 h after administration of 50, 100, or 150 μg (680 ± 140 MBq) of [^99mTc]Tc-BQ0413 in five PCa patients per injected mass (NCT05839990). All injection

SUBMITTER: Medvedeva A 

PROVIDER: S-EPMC11915028 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature