Nitric Oxide Activatable Photodynamic Therapy Agents Based on BODIPY-Copper Complexes.

ABSTRACT: In this work, two BODIPY-bipyridine Cu²⁺ ion complexes for targeted nitric oxide (NO) activatable photodynamic therapy are reported. The design is based on the relatively high concentration of these small gas molecules in the tumor microenvironment. Copper(II) ion complexation to the photosensitizer renders it in the OFF position in terms of fluorescence and reactive oxygen species (ROS) production. The interaction of the Cu²⁺-BODIPY complex with nitric oxide interchanges both fluorescence and therapy mode into the ON state through the detachment of the cation. Therefore, targeting the cancer cells would be expected to be achieved in this way. Moreover, one of the compounds, AP5, has increased aqueous solubility due to the polar structure. The designed structur

SUBMITTER: Ilhan H 

PROVIDER: S-EPMC11915034 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature