Gender-Affirming Hormone Therapy and Depressive Symptoms Among Transgender Adults.

ABSTRACT:

Importance

In the US, transgender, nonbinary, and gender diverse (TGD) adults have high rates of depression. Gender-affirming hormone therapy (GAHT) is associated with improved mental health outcomes, yet existing US studies have short follow ups and lack sample diversity.

Objective

To evaluate the use of GAHT delivered in primary care as an intervention for moderate-to-severe depressive symptoms in diverse TGD adult patients.

Design, setting, and participants

LEGACY was an observational cohort study conducted in federally qualified community health centers in Boston and New York that followed up TGD patients (N = 3592) from calendar years 2016 to 2019 (48 months). Participants included individuals aged 18 years or older, gender identity different from sex at birth, a

SUBMITTER: Reisner SL 

PROVIDER: S-EPMC11915065 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature