Interaction Between Traffic-Related Air Pollution and Parkinson Disease Polygenic Risk Score.

ABSTRACT:

Importance

Genetic and environmental factors are linked to Parkinson disease (PD), but the role of genetic susceptibility in the association between traffic-related air pollution (TRAP) and PD remains unclear.

Objective

To assess the gene-environment interaction between the polygenic risk score (PRS) for PD and long-term TRAP exposure and to estimate the joint effect with PD risk.

Design, setting, and participants

This population-based case-control study used a meta-analytical assessment of studies conducted in central California and Denmark. The Parkinson Environment and Genes (PEG) study in California (June 1, 2000, to July 31, 2017) included 634 patients with PD and 733 controls; the Parkinson Disease in Denmark (PASIDA) study (January 1, 2006, to December 31, 2017

SUBMITTER: Kwon D 

PROVIDER: S-EPMC11915066 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature