Patients with unilateral patellofemoral pain have altered bone turnover in the painful knee compared to the pain-free knee at rest and after acute knee loading.

ABSTRACT:

Objective

The objective of this study was to investigate subchondral bone turnover at rest and after acute loading using Fluorine-18-labeled sodium fluoride (Na[¹⁸F]F) Positron Emission Tomography (PET), in patients with unilateral PFP.

Design

Twenty-seven patients with unilateral PFP were recruited from the Institute of Sports Medicine Copenhagen. Participants underwent Na[¹⁸F]F-PET imaging before and after a bout of single-leg squats. Bone turnover measures, including mean and maximal standardized uptake value (SUV_mean and SUV_max), rate of bone perfusion (K1), rate of tracer uptake into bone (Ki), and extraction fraction of tracer absorbed into bone mineral were assessed for patella and trochlea.

Results

At rest, the painf

SUBMITTER: Hansen R 

PROVIDER: S-EPMC11915147 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature