Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers.

ABSTRACT:

Background

Micronutrient intake was inversely associated with cancer and cardiovascular risk in previous studies, but obtained results were inconsistent and the biological mechanisms for this potential protective effect remain elusive. Therefore, we investigated the associations of serum vitamin C, 25(OH)D, α-tocopherol, β-carotene, lycopene, folate, and iron with all-cause, cancer, and cardiovascular mortality. We further evaluated whether these associations were mediated through altered inflammatory responses.

Methods

Data were obtained from 11,539 participants aged ≥40 years in the National Health and Nutrition Examination Survey (NHANES) in 2001-2006 and 2017-2018. Mortality status of the participants with an average follow-up of 10.5 years was ascertained from the linke

SUBMITTER: Liu C 

PROVIDER: S-EPMC11915157 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature