Metabolic memory in gestational diabetes enhances SARS-CoV-2 susceptibility in postpartum women: a prospective cohort study integrated with longitudinal metabolomics.

ABSTRACT:

Objective

Women with gestational diabetes mellitus (GDM) often develop a metabolic memory that increases the risk of future metabolic disorders, even after blood glucose levels normalize following clinical intervention. However, the impact of this metabolic memory on susceptibility to SARS-CoV-2 remains unclear. Therefore, we aim to investigate the potential association between metabolic memory in GDM and susceptibility to SARS-CoV-2 infection.

Methods

We conducted a prospective cohort study with 1,675 pregnant women, including 197 (11.8%) with GDM. Postpartum SARS-CoV-2 infections were tracked via telephone follow-up and categorized into negative and positive groups. Logistic regression was used to explore risk factors for SARS-CoV-2 infection. Peripheral blood samples were

SUBMITTER: Li Z 

PROVIDER: S-EPMC11915492 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature