Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS tumours.

ABSTRACT:

Background

Liquid biopsy represents a major development in cancer research, with significant translational potential. Similarly, it is increasingly recognized that multi-omic molecular approaches are a powerful avenue through which to understand complex and heterogeneous disease biology. We hypothesize that merging these two promising frontiers of cancer research will improve the discriminatory capacity of current models and allow for improved clinical utility.

Methods

We have compiled a cohort of patients with glioblastoma, brain metastasis, and primary central nervous system lymphoma. Cell-free methylated DNA immunoprecipitation (cfMeDIP) and shotgun proteomic profiling was obtained from the cerebrospinal fluid (CSF) of each patient and used to build tumour-specific classi

SUBMITTER: Landry AP 

PROVIDER: S-EPMC11915530 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature