Correlation between serum complement component 4 levels and tubular atrophy in patients with lupus nephritis.

ABSTRACT:

Objective

The aim of this study is to examine the relationship between serum complement component 4 (C4) levels and tubular atrophy in patients with lupus nephritis (LN).

Methods

Patients diagnosed with LN through renal biopsy were retrospectively analyzed and categorized into two groups: the tubular atrophy group (TA group) and the non-tubular atrophy group (non-TA group). Demographic data, clinical characteristics, and pathological findings were compared between the groups. Logistic regression and spline smoothing plot analysis, utilizing the generalized additive mixed model, were employed to investigate the relationship between serum C4 levels and the occurrence of tubular atrophy.

Results

A total of 129 patients were included in the study, with 57 (44.2%) identifi

SUBMITTER: Chang Z 

PROVIDER: S-EPMC11915727 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature