Genetic insights into blood urea nitrogen as a risk factor for coronary artery disease: a Mendelian randomization study in East Asians.

ABSTRACT:

Background

Previous studies have reported the association between blood urea nitrogen (BUN) and cardiovascular diseases (CVDs) but the causality has not yet been proved. Our study aimed to assess the causal effect of BUN levels on several CVDs using the two-sample Mendelian randomization (MR) method. This is the first MR study examining causal relationships between BUN and multiple cardiovascular diseases.

Methods

Using data from genome-wide association studies (GWAS) of East Asians, we identified single nucleotide polymorphisms (SNPs) associated with BUN levels as instrumental variables. Specifically, SNPs reaching genome-wide significance (p < 5 × 10^-8) were selected from a large-scale BUN dataset comprising (n = 148,767). To ensure robustness, mul

SUBMITTER: Shen L 

PROVIDER: S-EPMC11915739 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature