Analysis of co-occurrence of type II toxin-antitoxin systems and antibiotic resistance determinants in <i>Staphylococcus aureus</i>.

ABSTRACT: Toxin-antitoxin (TA) systems consist of toxic proteins and their inhibitors, and were originally shown to ensure plasmid maintenance in bacterial populations. Over time, however, TA systems have also been identified on bacterial chromosomes, raising questions about their roles unrelated to plasmid stability. Among the eight currently recognized types of TA systems, type II has been the most extensively investigated. Type II systems are often found in pathogenic bacterial species, including staphylococci. Staphylococcus aureus, a notorious human pathogen, harbors multiple type II TA systems, both plasmid- and chromosome-encoded, while their potential relation to virulence remains to be addressed. Here, we investigate the co-occurrence of TA systems and antibiotic resistance (AR) dete

SUBMITTER: Bukowski M 

PROVIDER: S-EPMC11915791 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature