Multi-omics analysis reveals associations between gut microbiota and host transcriptome in colon cancer patients.

ABSTRACT: Colon cancer (CC) is one of the most common cancers globally, which is associated with the gut microbiota intimately. In current research, exploring the complex interaction between microbiomes and CC is a hotspot. However, the information on microbiomes in most previous studies is based on fecal, which does not fully display the microbial environment of CC. Herein, we collected mucosal and tissue samples from both the tumor and normal regions of 19 CC patients and clarified the composition of mucosal microbiota by 16S rRNA and metagenomic sequencing. Additionally, RNA-Seq was also conducted to identify the different expression genes between tumor and normal tissue samples. We revealed significantly different microbial community structures and expression profiles to CC. Depending on correla

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11915798 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature