Evolutionary trajectory of bacterial resistance to antibiotics and antimicrobial peptides in <i>Escherichia coli</i>.

ABSTRACT: The global crisis of antimicrobial resistance poses a major threat to human health, underscoring the urgency of developing new antibacterial strategies. Antimicrobial peptides (AMPs) are promising alternatives to antibiotic therapy, yet potential microbial resistance is of great concern. Resistance is often accompanied by fitness costs, which may in turn influence the spread of drug-resistant bacteria and their susceptibility to other antimicrobial agents. Herein, we investigate the evolutionary trajectory of bacterial resistance to antibiotics and AMPs in Escherichia coli, and evaluate the fitness costs and collateral sensitivity of drug-resistant strains. We reveal that E. coli develops resistance to antibiotics, particularly ciprofloxacin and kanamycin, at a notably faster

SUBMITTER: Yu F 

PROVIDER: S-EPMC11915801 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature