Contrasting roles of PSGL-1 and PD-1 in regulating T-cell exhaustion and function during chronic viral infection.

ABSTRACT: Immune checkpoints are critical regulators of T-cell exhaustion, impairing their ability to eliminate antigens present during chronic viral infections. Current immune checkpoint inhibitors (ICIs) used in the clinic aim to reinvigorate exhausted T cells; yet, most patients fail to respond or develop resistance to these therapies, underscoring the need to better understand these immunosuppressive pathways. PSGL-1 (Selplg), a recently discovered immune checkpoint, negatively regulates T-cell function. We investigated the cell-intrinsic effects of PSGL-1, PD-1, and combined deletion on CD8⁺ T cells during chronic viral infection. We found that combined PSGL-1 and PD-1 (Selplg^-/-Pdcd1^-/-) deficiency in CD8⁺ T cells increased their freque

SUBMITTER: Viramontes KM 

PROVIDER: S-EPMC11915808 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature