Tracing the evolution: the rise of <i>Salmonella</i> Thompson co-resistant to clinically important antibiotics in China, 1997-2020.

ABSTRACT: As clinical Salmonella enterica serovar Thompson (S. Thompson) emerged among the top ten prevalent serovars in China, understanding the distribution and origin of its multidrug-resistant (MDR) strains becomes imperative. This study employed antimicrobial susceptibility testing, whole-genome sequencing, and bioinformatics analysis to investigate the prevalence and genomic profiles of clinically important S. Thompson ST26 across China from 1997 to 2020. Upon analyzing 141 isolates from various sources, we identified 29 isolates, derived from 25 diarrhea patients and four animal-derived foods, displayed co-resistance to ciprofloxacin, cefotaxime, and azithromycin (CIP^RCTX^RAZI^R), all of which are considered the front-line and critically-imp

SUBMITTER: Zhai W 

PROVIDER: S-EPMC11915813 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature