Emerging <i>Clostridioides difficile</i> ribotypes have divergent metabolic phenotypes.

ABSTRACT: Clostridioides difficile is a gram-positive spore-forming pathogen that commonly causes diarrheal infections in the developed world. Although C. difficile is a genetically diverse species, certain ribotypes are overrepresented in human infections, and it is unclear if metabolic adaptations are essential for the emergence of these epidemic ribotypes. To identify ribotype-specific metabolic differences, we therefore tested carbon substrate utilization by 88 C. difficile isolates and looked for differences in growth between 22 ribotypes. As expected, C. difficile was capable of growing on a variety of carbon substrates. Further, C. difficile strains clustered by phylogenetic relationship and displayed ribotype-specific and clade-specific metabolic cap

SUBMITTER: Midani FS 

PROVIDER: S-EPMC11915817 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature