Fecal bacterial biomarkers and blood biochemical indicators as potential key factors in the development of colorectal cancer.

ABSTRACT: The incidence of colorectal cancer (CRC) has been increasing in recent decades. Current methods for CRC screening have their own drawbacks, thus there is an urgent need to identify the key microbes that drive the development of CRC for wider application in the early detection and prevention of CRC. To address this issue, we performed fecal microbiome analysis by high-throughput sequencing of 16S rRNA gene combined with blood biochemical indicators in patients with CRC stages I, II, III, and IV, healthy people, and patients with polyps. Fecal microbiota of patients with CRC was disturbed, as evidenced by significantly reduced α-diversity in patients with CRC stage IV and markedly different β-diversity. The random forest model identified the top 25 genera from 174 training data, resulting in

SUBMITTER: Cai P 

PROVIDER: S-EPMC11915818 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature