Characterization and therapeutic potential of newly isolated bacteriophages against <i>Staphylococcus</i> species in bovine mastitis.

ABSTRACT: Bovine mastitis, primarily caused by Staphylococcus aureus, significantly affects the dairy industry by reducing milk production and quality. The rise of antibiotic-resistant bacteria has prompted the need for alternative treatments. The three newly isolated bacteriophages, OPT-SA02, OPT-SC01, and OPT-SX11, were isolated from chicken fecal and sewage samples in South Korea. These bacteriophages were characterized via physiological and genomic analyses, identifying their therapeutic potential against S. aureus-induced mastitis. The bacteriophages were identified as members of the Herelleviridae family, exhibiting stability across broad pH (2-12) and temperature (37-70°C) ranges, as well as strong antibacterial activity at low multiplicity of infection (MOI) levels. Geno

SUBMITTER: Cho J-h 

PROVIDER: S-EPMC11915829 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature