Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice.

ABSTRACT: Type III interferons (IFNs) primarily act on epithelial cells and protect against virus infection of the mucosa, whereas type I IFNs act more systemically. To date, it has been unknown which epithelial subtypes in the upper airways, the primary site for initial infection for most respiratory viruses, primarily rely on type III IFN or type I IFNs for antiviral protection. To address this question, we performed a single-cell transcriptomics analysis of the epithelial IFN-mediated response focusing on the upper airways of mice. This work identified nine distinct cell types derived from the olfactory epithelium and thirteen distinct cell types from the respiratory epithelium. Interestingly, type I IFNs induced a stronger antiviral transcriptional response than type III IFN in respiratory epith

SUBMITTER: Wang X 

PROVIDER: S-EPMC11915831 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature