YTHDF1 and YTHDC1 m⁶A reader proteins regulate HTLV-1 <i>tax</i> and <i>hbz</i> activity.

ABSTRACT: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease. Regulation of viral gene expression plays a key role in viral persistence and pathogenesis. However, the molecular mechanisms underlying this fine-tuned regulation remain poorly understood. Little is known regarding RNA chemical modifications of HTLV-1 RNA and how these affect viral biology and disease development. Post-transcriptional chemical modification of RNA is common in eukaryotes, with N⁶-methyladenosine (m⁶A) being the most prevalent. In this study, we investigated the role of m⁶A RNA modifications on HTLV-1 gene expression.

SUBMITTER: King EM 

PROVIDER: S-EPMC11915865 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature