Apoptosis Inhibitor of Macrophage (CD5-Like Antigen) in Healthy Dogs and Dogs With Acute Kidney Injury.

ABSTRACT:

Background

Apoptosis inhibitor of macrophage (AIM) is a fundamental mediator of recovery from acute kidney injury (AKI) in mice, but its role in AKI in dogs is unknown.

Hypothesis/objectives

To detect and quantify AIM in serum and urine from both healthy dogs and dogs with AKI, and to determine if AIM is higher in dogs with AKI compared to healthy controls.

Animals

Eight dogs with International Renal Interest Society (IRIS) Grade II-V AKI and 10 healthy adult dogs.

Methods

Retrospective case-control study. Liquid chromatography-mass spectrometry (LC-MS) based targeted proteomics was used to quantify AIM. AIM peak areas were compared between the AKI and healthy cohorts and correlated with selected markers of renal function.

Results

AIM was able to be quan

SUBMITTER: Whitehouse WH 

PROVIDER: S-EPMC11915910 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature