Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.

ABSTRACT:

Background

This review updates our understanding of the neuroanatomical and neurocircuitry factors involved in panic disorder (PD). Many aspects remain undetermined.

Methods

Clinical studies and a randomized controlled trial were identified via PubMed database and included in this review.

Results

The search, following PRISMA guidelines, identified 13 human studies and 3 animal studies. Nine human studies compared brain activity and connectivity between regions in PD patients. Neural activity in the amygdala was highlighted in six studies. The hippocampus had higher activation in PD patients compared to those with social phobia, but generally showed less activity compared to healthy controls. The parahippocampal gyrus and thalamus exhibited greater activation in PD pat

SUBMITTER: Kyriakoulis P 

PROVIDER: S-EPMC11916057 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature