Changes in aqueous humor cytokines and metabolomics in contralateral eye after unilateral cataract surgery.

ABSTRACT:

Background

For patients with bilateral age-related cataracts, sequential phacoemulsification and intraocular lens implantation is a common treatment. However, it remains unclear whether surgery on the first eye has an impact on the second eye, as current research results are inconsistent. This study will explore whether surgery on one eye affects the non-operated eye through aqueous humor cytokines and metabolomic analyses in the second eye.

Methods

A rabbit model of unilateral phacoemulsification and intraocular lens implantation was established. The experimental group consisted of 15 rabbits undergoing this procedure. Postoperatively, rabbits were divided into five subgroups (three rabbits per subgroup), and aqueous humor was collected from both the operated and non-operat

SUBMITTER: Li Y 

PROVIDER: S-EPMC11916942 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature