Therapeutic Targets for Gastric Cancer: Mendelian Randomization and Colocalization Analysis.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most prevalent malignancies in the world. Most patients are diagnosed at advanced stages of the disease, primarily attributable to the insidious nature of early symptoms and the infrequent occurrence of routine screening. Further biomarkers are still needed for more comprehensive analysis, targeted prognostication, and effective treatment strategies. Plasma proteins are promising biomarkers and potential drug targets in GC. This study aims to identify potential therapeutic targets for GC by conducting a comprehensive proteome-wide Mendelian randomization (MR) and colocalization analyses.

Methods

Plasma proteins were obtained from the UK Biobank Pharma Proteomics Project (UKB-PPP), including Genome-Wide Association Study(GWAS)data

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11916961 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature