Do CRP gene variants and smoking elevate recurrent stroke risk in minor ischemic stroke patients?

ABSTRACT:

Background

Minor ischemic strokes, despite their initial mild symptoms, pose a significant risk of recurrence, potentially leading to severe disability. The role of C-reactive protein (CRP) gene variants in predicting the recurrent minor stroke, particularly their interaction with lifestyle factors such as smoking, remains unclear. We aimed to investigate the relationship of single-nucleotide polymorphisms (SNPs) in CRP gene with minor stroke recurrence, focusing on gene-environment interactions.

Methods

A retrospective cohort study was conducted using data from the stroke registry at Linfen People's Hospital, including 2032 first-time minor stroke patients (NIHSS score ≤ 5) admitted within 7 days of symptom onset from January 2019 to December 2022. Follow-up assessments wer

SUBMITTER: Li X 

PROVIDER: S-EPMC11916976 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature