Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients.

ABSTRACT:

Background

Depression in late-life is linked to an increased risk of Alzheimer's dementia (AD), with the risk potentially varying according to the age at onset of depression. Previous studies have typically dichotomized depression onset ages between 55 and 65 years; however, the specific age at which depression onset increases AD risk in older adults remains unclear. In this study, we aimed to investigate the relationship between the age at onset of depression and AD risk, and compare the characteristics between different age groups.

Methods

A longitudinal cohort of 251 older patients diagnosed with major depressive disorder was followed for up to 22 years. Participants were categorized into four groups based on depression onset age: ≤ 54 years, 55-64, 65-74, and ≥ 75 years.

SUBMITTER: Jang YJ 

PROVIDER: S-EPMC11917000 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature