Ketamine as adjuvant treatment in eating disorders: an exploratory study of a case series and retrospective analysis.

ABSTRACT:

Background

Eating disorders (EDs) significantly impair physical health and psychosocial functioning. Few effective therapeutic approaches exist for EDs, particularly in Anorexia Nervosa (AN). The use of ketamine, already characterized as a noncompetitive NMDA antagonist anesthetic in depression and suicidal ideations, could be an innovative adjuvant treatment for the AN spectrum.

Methods

We describe a case series of eight patients treated with intravenous Ketamine Adjuvant Treatment (KAT) combined with usual care. We also review the literature and discuss the theoretical mechanisms behind the influence of KAT in EDs. Our patients were all female, with a diagnosis of AN spectrum, and aged between 16 and 44. We offered KAT attempting to remodel rigid food-centered thoughts. So

SUBMITTER: Escobedo-Aedo PJ 

PROVIDER: S-EPMC11917004 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature