Gut microbiota metabolites impact immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men.

ABSTRACT:

Background

The association between gut microbial metabolites and immunologic non-response among people living with HIV (PLHIV) receiving antiretroviral therapy (ART) has not been well established. We aimed to characterize gut microbial metabolites among HIV-infected men who have sex with men (MSM) with different immunologic responses.

Methods

We recruited HIV-infected MSM from Guangzhou Eighth People's Hospital and HIV-uninfected MSM (healthy controls, HC) from a local MSM community-based organization in Guangzhou between June and October 2021. HIV-infected MSM were grouped into good immunological responders (GIR) (CD4 + T cell count ≥ 350 cells/μl) and poor immunological responders (PIR) (CD4 + T cell count < 350 cells/μl) after 24 months of ART treatment. Online questionna

SUBMITTER: Feng A 

PROVIDER: S-EPMC11917012 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature