Perivascular space and white matter hyperintensities in Alzheimer's disease: associations with disease progression and cognitive function.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles. Recent studies emphasize the role of vascular factors, including the glymphatic system, in AD pathogenesis, particularly in Aβ clearance. The diffusion tensor image analysis along the perivascular space (DTI-ALPS; ALPS-Index) has emerged as a novel, non-invasive method to evaluate the glymphatic system in vivo, showing glymphatic insufficiency in AD. This study aimed to investigate alterations in the function of the glymphatic system in individuals with AD versus healthy controls (HC), and to explore its association with Aβ, cerebrovascular disease (CVD), white matter hyperintensities (WMH), and cognitive function.

Methods

SUBMITTER: Schirge PM 

PROVIDER: S-EPMC11917016 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature