Association of maternal prenatal phthalate exposure and genetic polymorphisms of metabolic enzyme genes with spontaneous preterm birth: a nested case-control study in China.

ABSTRACT:

Background

The relationship between prenatal phthalate exposure and preterm birth from previous studies has been inconsistent. Meanwhile, few studies have explored the relationship between spontaneous preterm birth (SPTB) and genetic polymorphisms of metabolic enzyme genes or gene-phthalate interactions. The aim of this study is to evaluate the association of maternal phthalate exposure, genetic polymorphisms, and their interactions with SPTB.

Methods

A total of 182 cases with SPTB and 321 controls with full-term delivery were enrolled. Nine phthalate metabolites in maternal second trimester urine samples were measured by ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Genotyping was performed on twenty-six single nucleotide polymorphisms

SUBMITTER: Li N 

PROVIDER: S-EPMC11917035 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature