Association between NAT10 gene rs8187 G > A polymorphism and Wilms tumor susceptibility in Chinese Han children: a five-center case-control study.

ABSTRACT:

Background

Wilms tumor, a prevalent pediatric kidney cancer, has been extensively studied to elucidate its genetic mechanisms. NAT10 (N-acetyltransferase 10) is a gene encoding acetyltransferase, which is involved in various cellular processes, including RNA modification, DNA repair, and protein acetylation. The oncogenic role of NAT10 in cancer has garnered significant attention. However, research on NAT10 genetic variants and their associations with cancer is nascent.

Methods

This study investigated the link between NAT10 genetic variants and Wilms tumor risk via a case‒control design with genomic DNA from 414 patients and 1199 controls. Genotyping was performed via the TaqMan method, and logistic regression statistical analysis was conducted to identify significant associ

SUBMITTER: Deng C 

PROVIDER: S-EPMC11917036 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature