Laparoscopic lavage in a purulent peritonitis model: impact on inflammatory proteins.

ABSTRACT:

Background

Laparoscopic lavage is an effective, safe, and feasible treatment in patients with perforated diverticulitis with purulent peritonitis. Laparoscopic lavage was introduced without any detailed knowledge regarding the mechanisms of action. The aim of this study was to validate the reproducibility of an animal model of purulent peritonitis and to study the effect of laparoscopic lavage on inflammatory proteins in this model.

Methods

Forty rats, divided into eight groups (n = 5) were operated. Six groups underwent cecal ligation and puncture (CLP) causing peritonitis and two groups underwent sham surgery. Three CLP and one sham group received laparoscopic lavage, while the remaining groups acted as time-matched controls. Samples of abdominal fluid and blood were colle

SUBMITTER: Sinclair E 

PROVIDER: S-EPMC11917159 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature