Decreased Serum and Salivary Levels of Aquaporin 5 in Oral Lichen Planus.

ABSTRACT:

Objectives

Oral lichen planus (OLP) is an autoimmune disease with unknown etiology. Many OLP patients complain of xerostomia, and studies are still ongoing to find the reason for this manifestation. Aquaporin 5 has been expressed in salivary glands, and its physiological significance in transferring water as transcellular is properly identified. In this study, for the first time, we have investigated the serum and salivary levels of aquaporin 5 (as a salivary gland biomarker) in oral lichen planus patients with xerostomia.

Material and methods

Thirty patients with OLP and xerostomia and 30 healthy individuals were chosen. The flow of stimulatory and non-stimulatory saliva was calculated, and the serums, in addition to salivary levels of aquaporin 5, were determined.

Resul

SUBMITTER: Agha-Hosseini F 

PROVIDER: S-EPMC11917382 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature