Genome-wide association study and subsequent functional analysis reveal regulatory mechanism underlying piglet diarrhea.

ABSTRACT:

Objective

Piglet diarrhea poses a serious threat to piglet health and the livestock economy, and is one of the most pressing problems in animal husbandry. This study aims to investigate the genetic factors involved in piglet diarrhea and to identify key genes that regulate this condition.

Methods

We screened 600 diarrheal piglets based on unique diarrhea scores for resequencing and conducted a genome-wide association study (GWAS). Through this process, we identified 308 single nucleotide polymorphisms (SNPs) and annotated 151 candidate genes. Extensive functional validation and systematic analysis were performed on key candidate genes KSR1, SKAP1, SLC35F6, and OR12.

Results

The study found that the four key genes were involved in the regulation of piglet diarrhea thro

SUBMITTER: Chen D 

PROVIDER: S-EPMC11917426 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature