Membrane lipid composition directs the cellular selectivity of antimicrobial metallohelices.

ABSTRACT: Two enantiomeric pairs of iron(ii) metallohelices, available as water-soluble, stable, and optically pure bimetallic complexes, differ principally in the length of the central hydrophobic region between two cationic domains, and have distinct activity and cell selectivity profiles against Gram-positive and Gram-negative microbes. The effects of dose concentration and temperature on levels of intracellular accumulation in E. coli and S. aureus, studied via isotopic labelling, indicate that the metallohelices enter the microbial cells via passive diffusion, whereupon (as previously determined) they act on intracellular targets. Whilst the metallohelices with the shorter central hydrophobic regions accumulate less readily than those with the longer hydrophobic brid

SUBMITTER: Rogers NJ 

PROVIDER: S-EPMC11917443 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature