Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.

ABSTRACT: Having alternative infection routes is thought to help parasites circumvent host resistance, provided that these routes are associated with different host resistance loci. This study tests this postulate by examining whether alternate infection routes of the parasite Pasteuria ramosa are linked to distinct resistance loci in its crustacean host, Daphnia magna. We focus on the P. ramosa isolate P15, which can attach and penetrate the host through either the hindgut or the foregut. Using a global panel of 174 D. magna genotypes supplemented with breeding experiments, we analyzed resistance patterns for each of these infection routes. Our findings confirm our hypothesis in D. magna, hindgut attachment is determined by the D locus, while foregut attachment is controlled by a newly identified G

SUBMITTER: Mathieu-Begne E 

PROVIDER: S-EPMC11917490 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature