Estrogen prevented gingival barrier injury from <i>Porphyromonas gingivalis</i> lipopolysaccharide.

ABSTRACT: The postmenopausal population usually suffers from more severe periodontal disease than non-menopausal women due to the decrease and low levels of estrogen, especially β-estradiol (E2). While additional estrogen therapy can effectively relieve alveolar bone resorption, this suggests that estrogen has played an important role in the development of periodontitis. The integrity of the gingival epithelial barrier plays a key role in protecting gingival tissue from inflammatory injury caused by pathogens. However, it remains unclear whether estrogen can maintain the integrity of the gingival epithelial barrier to reduce inflammatory injury. Here, using an infection model established with Porphyromonas gingivalis lipopolysaccharide (LPS) in human gingival epithelial cells (hGECs) and ovar

SUBMITTER: Huang F 

PROVIDER: S-EPMC11918251 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature