Time-of-day dependent promotion of keratinocyte differentiation by Cinnamomum cassia bark extract through the p38 MAPK Pathway.

ABSTRACT: The skin serves as an essential barrier against pathogens and external insults, preventing moisture loss. Chronic skin conditions such as atopic dermatitis stem from impairments in skin barrier function. Circadian rhythms affect skin blood flow and barrier characteristics, which are significant for understanding atopic dermatitis. Cinnamomum cassia bark, commonly known as cinnamon, is extensively utilized in both modern and Traditional Chinese Medicine for its therapeutic properties in managing chronic diseases. This study aimed to investigate the potential use of Cinnamomum cassia bark in enhancing skin barrier function. We examined the impact of Cinnamomum cassia bark extract (CCBE) on circadian clock-mediated enhancement of the skin barrier. CCBE enhanced the expression of keratinocyte

SUBMITTER: Yeom M 

PROVIDER: S-EPMC11918335 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature