The efficacy and safety of acetazolamide in chronic mountain sickness: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

The impact of acetazolamide (ACZ) in chronic mountain sickness (CMS) has not been fully assessed. The purpose of this systematic review is to evaluate the effectiveness and safety of acetazolamide in the treatment of chronic mountain sickness.

Research methods

This systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The primary outcome measure was CMS clinical score. Secondary outcomes included CMS total score,hematocrit (HCT), Pondus Hydrogenii‌ (pH), arterial oxygen pressure (PaO2), arterial carbon dioxide pressure (PaCO2), bicarbonate concentration (HCO3), and adverse events.

Results

Five randomized controlled trials were included, comprising a total of 13

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11918342 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature