Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes.

ABSTRACT: Genotype-based approaches for the estimation of SNP-based narrow-sense heritability ([Formula: see text]) have limited utility in pregnancy-related outcomes due to confounding by the shared alleles between mother and child. Here, we propose a haplotype-based approach to estimate the genetic variance attributable to three haplotypes - maternal transmitted ([Formula: see text]), maternal non-transmitted ([Formula: see text]) and paternal transmitted ([Formula: see text]) in mother-child pairs. We show through extensive simulations that our haplotype-based approach outperforms the conventional and contemporary approaches for resolving the contribution of maternal and fetal effects, particularly when m1 and p1 have different effects in the offspring. We apply this approach to estimate the expl

SUBMITTER: Srivastava AK 

PROVIDER: S-EPMC11918446 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature