Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia.

ABSTRACT: Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age-related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage-gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL/6J mice to explore age-related alterations in their voltage-gated ionic currents (n > 30 patches, eight mice in each group). We observed that the voltage-gated inward sodium current (peak I_Na(Max)) was significantly decreased with aging in the SG, but not in the ve

SUBMITTER: Lee B 

PROVIDER: S-EPMC11918529 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature