The Broad Spectrum of <i>TP53</i> Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots.

ABSTRACT: TP53 aberrations are a major predictive factor of resistance to chemoimmunotherapy in chronic lymphocytic leukemia (CLL), and an assessment of them before each line of treatment is required for theranostic stratification. Acquisition of subclonal TP53 abnormalities underlies the evolution of CLL. To better characterize the distribution, combination, and impact of TP53 variants in CLL, 1,056 TP53 variants collected from 683 patients included in a multicenter collaborative study in France were analyzed and compared to UMD_CLL, a dataset built from published articles collectively providing 5,173 TP53 variants detected in 3,808 patients. Our analysis confirmed the presence of several CLL-specific hotspot mutations, including a two-base pair deletion in codon

SUBMITTER: Lazarian G 

PROVIDER: S-EPMC11918887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature