Predicting Conversion From Unipolar Depression to Bipolar Disorder and Schizophrenia: A 10-Year Retrospective Cohort Study on 12,182 Inpatients.

ABSTRACT: Background: The initial stages of bipolar disorder (BD) and schizophrenia (SCZ) often exhibit depressive symptoms and syndromes, leading to potential misdiagnosis and treatment for unipolar depression (UD). However, no consensus exists on individualized and time-varying intervenable conversion predictors for both BD and SCZ. Methods: This study examined the rate of true conversion from UD to BD and SCZ, considering factors such as sex, family history of mental illness, psychotic features, recurrent depression, and treatment patterns. The objective was to develop predictive models for short-, medium-, and long-term risk stratification for BD/SCZ conversion. Data were extracted from electronic medical records (EMRs) between January 2009 and December 2020 in a large academic med

SUBMITTER: Zhu T 

PROVIDER: S-EPMC11919011 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature