Disparities in Plasma Homocysteine Levels Between Early-Onset and Late-Onset Depression.

ABSTRACT: Background: Elevated homocysteine levels and late-life depression are risk factors for cognitive decline: a comparative study highlighted the association of late-onset depression (LOD) with more significant cognitive deficits and brain pathology than early-onset depression (EOD). Limited research has explored the possible interaction between homocysteine levels and their correlation with cognitive performance in patients with EOD and LOD. Methods: Fifty-seven individuals with EOD, 56 with LOD, and 89 matched healthy controls (HC) were recruited. Global cognition, memory, execution, language, attention, visuospatial skills, and plasma homocysteine levels were examined. Results: Compared with HC and patients with EOD, patients with LOD had higher plasma homocysteine leve

SUBMITTER: Wang T 

PROVIDER: S-EPMC11919066 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature