Shared and Unique Genetic Links between Neuroticism and Gastrointestinal Tract Diseases.

ABSTRACT:

Objective

Association between neuroticism and gastrointestinal tract (GIT) diseases may not be attributable to the genetic overlaps between neuroticism and psychiatric disorders. We aim to explore the genetic links and mechanisms of neuroticism and GIT diseases.

Materials and methods

We obtained European genome-wide association data of neuroticism (n = 390,278) or subclusters (depressed, n = 357,957; worry, n = 348,219) and six GIT diseases: gastroesophageal reflux disease (GERD, n = 456,327), inflammatory bowel disease (IBD, n = 456,327), peptic ulcer disease (PUD, n = 456,327), irritable bowel syndrome (IBS, n = 486,601), Crohn's disease (CD, n = 20,883), and ulcerative colitis (UC, n = 21,895). We performed ge

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11919111 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature