Heterogeneous Brain Atrophy Sites in Anxiety Disorders Map to a Common Brain Network.

ABSTRACT:

Background

Heterogeneous findings among anxiety disorder studies have hindered elucidation of the underlying pathophysiology and the development of mechanism-based therapies.

Purpose

To determine whether structural MRI findings in anxiety disorder studies converge on a common network with therapeutic significance.

Materials and methods

In this retrospective study, a systematic literature search of PubMed and Web of Science databases was performed to identify coordinates of gray matter atrophy in patients with anxiety disorder. Atrophy coordinates were then mapped to an anxiety network constructed from the resting-state functional MRI (rs-fMRI) data of 652 healthy participants using "coordinate network mapping" and validated by specificity tests. The causal association

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11919243 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature